Can patient know he has IgA nephropathy without taking renal biopsy? Unfortunately, renal biopsy is essential in the diagnosis of IgA nephropathy, even though it is painful.
IgA nephropathy is an autoimmune kidney disease, which is caused by the accumulation of immune complexes in glomerular filtration membrane, and IgA immunoglobulin is the major sediment.
Are there any other tests needed in the diagnosis except for renal biopsy?
Except for renal biopsy, patient with IgA nephropathy also needs many other tests to diagnose his disease, like urine test, blood test, and some image tests may also be necessary.
In the urine test, whether patient has hematuria and proteinuria is very useful in assessing patient’s kidney condition and its prognosis.
Why renal biopsy is essential in the diagnosis of IgA nephropathy?
As we know, there are many tests in diagnosing kidney disease, which are also very effective. But in the diagnosis of IgA nephropathy, renal biopsy is very necessary.
A major reason of the necessity of renal biopsy is the lesion caused by IgA nephropathy appears in glomerular filtration membrane, which will cause more serious glomerular damage gradually, and many kidney diseases can cause patient to have lesion in glomeruli, like FSGS, purpura nephritis, etc.
While many people may think since IgA nephropathy is caused by the accumulation of IgA immunoglobulin in glomeruli, so patient must have abnormal level of IgA immunoglobulin in body, which can be a foundation in diagnosing IgA nephropathy. In fact, many other diseases can cause the accumulation of IgA immunoglobulin in glomeruli, like purpura, and this disease can also cause purpura nephritis to patient.
Thereby, to diagnose patient’s kidney disease more exactly, renal biopsy is necessary in the diagnosis of IgA nephropathy.