At present, diabetes especially type 2 diabetes is the leading cause of chronic kidney disease in end stage. Making clear how diabetes damages kidneys can help diabetics prevent Diabetic Nephropathy effectively. Well then, how does diabetes attack kidneys?
Diabetes is one disease in which insulin secretion declines after β pancreatic cells’ damage, causing endocrine and metabolic disorder. As its name indicates, Diabetic Nephropathy is due to diabetes that attacks inherent kidney cells.
The characteristics of diabetic kidney disease is that kidneys won’t shrink in the early stage, and on the contrary, kidneys will become a little larger. However, in the end stage, patients’ kidneys will become smaller and smaller. The main cause is the long-term high blood sugar that induces the increase of the thickness of blood. Then, the blood flows slowly, and extra fat and dead blood cells will build up in vascular epithelial cells. Because of lack of blood and oxygen, kidney epithelial cells are damaged gradually, and its filtration rate declines. Accordingly, more and more waste products and toxins build up in the blood. In order to remove these waste products out of the body, kidneys have to work harder. The long-term overwork makes kidneys fail to work gradually. However, in this time, the damaged epithelial cells don’t get active and effective recovery. With the progression of patients’ illness condition, collagen formation increases, glomerular basement membrane becomes thicker, and glomerular sclerosis produces. Then, kidneys become smaller and smaller. If uncontrolled effectively, Diabetic Nephropathy will aggravate into end stage kidney failure gradually.
The above is one overview of Diabetic Nephropathy causes. If you still have anything unclear, you can leave a message below or email to firstname.lastname@example.org. We are glade to give you a big help.