Glomerular filtration rate (GFR) divides FSGS into 5 stages. Stage 4 FSGS means kidneys are functioning at 15%~29%. To get correct treatment plan, patients should find out the primary causes of Stage 4 FSGS. Today, we would like to introduce the primary causes of this disease.
In clinic, many factors can induce focal segmental glomerular sclerosis, and they are poisoning damage, humoral immune disorder, hemodynamic change, and so on. All of these disorders cause damage to capillary walls, so large molecular protein will produce and accumulate. Then, immunoglobin will accumulate and combine with C1q and C3, causing the regression of the podocytes and breaking away from basement membrane. Finally, glomerular epithelial cells and endothelial cells are damaged, and FSGS occurs.
If controlled timely, FSGS patients can get complete remission in clinic. Otherwise, they may eventually have end stage kidney failure. The progression of FSGS can be sped up by a large amount of protein intake, high blood pressure, proteinuria, misuse of medicines, and so on.
When kidneys lose 70%~85% function, it means the onset of Stage 4 FSGS. In this condition, patients must suffer from a series of kidney disease symptoms and complications such as swelling, proteinuria, high blood pressure, hematuria, anemia, and so on.
From the above content, we can find out the underlying cause of Stage 4 FSGS is due to immune disorder. In this case, patients should take some therapies to regulate their immune system and repair damaged glomerular epithelial cells and endothelial cells. When kidneys can do their work normally, patients’ symptoms and complications can be managed very well.
At present, Micro-Chinese Medicine Osmotherapy and Immunotherapy can help treat FSGS effectively. To determine which therapy is most suitable for you, you can leave your illness description in the below form.