Lupus Nephritis refers a kidney disorder, in which the filters (glomeruli) of kidneys are inflamed. It is a complication of systemic lupus erythematosus (SLE).
SLE is an autoimmune disease which may typically cause harm to the skin, joints, kidneys, and brain.
Normally, your immune system can protect your body from outside invaders and it can tell from the difference between the foreign harmful substances such as bacteria and virus and the stuff inside you (like your organs). However, in an autoimmune disease the immune system cannot tell the difference between harmful substances and healthy ones. As a result, the immune system attacks otherwise healthy cells and tissues.
SLE may damage different parts of kidneys thus resulting in Lupus Nephritis.
The causes of SLE are unknown yet. However, the following factors may affect the occurrence of SLE:
Gender and age: SLE is more common in young women.
Genetic factor: SLE may run in a family.
History of lupus
If you have a history of lupus, you are at high risk of developing Lupus Nephritis. Lupus Nephritis usually arises within 5 years of diagnosis of lupus. However, in the early stage of Nephritis, you may do not show noticeable symptoms or discomforts at all and the traditional tests may not be able to reflect the renal injury either. Immunological test is important to find Lupus Nephritis if you are at high risk but do not have symptoms and it also can improve its treatment outcome.
Anything that increases your chance of developing Lupus Nephritis is a risk factor. However, having risk factors does not mean you will get Lupus Nephritis. If you have risk factors, it is a good idea to discuss them with your heath care provider.
Lupus Nephritis is most common in women ages 20~40. The common risks of Lupus Nephritis include:
Genetic factor: If there is someone getting Lupus Nephritis, you are at risk of developing the disease.
Ultraviolet light: Expose to sunlight can put you at risk of developing lupus, especially among people who have sun-sensitive skin. If you have lupus you've probably already noticed that being exposed to too much sunlight can make your symptoms worse.
Smoking: Smoking can increase your risk for lupus.
Lupus Nephritis is a complication of systemic lupus erythematosus (SLE). It usually arises within in 5 yeas of diagnosis of SLE.
Although in most cases of SLE, the patients do not show clinical manifestation of renal disease, the histological abnormality is very evident in most patients. Estimates of the prevalence of clinical renal involvement in people with SLE rang from 30%~90%. In fact, Lupus Nephritis can affect more than half of people with SLE.
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