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Nephrotic Syndrome Secondary to Amyloidosis: Causes and Treatments

Nephrotic Syndrome Secondary to Amyloidosis: Causes and TreatmentsRenal amyloidosis refers to a large amount of amyloid fibril depositing in kidneys and causing renal lesion. In clinic, it mainly presents the form of Nephrotic Syndrome. If left alone, it may even aggravate into kidney failure. Today, we will talk about causes and treatments of Nephrotic Syndrome secondary to amyloidosis.


Because of immune disorder, protein metabolic disorder or degeneration of connective tissue decomposition, amyloid fiber forms. This substance's solubility is quite low in the physiological solution, so it may deposit in the tissues and extracellular region, resulting in the affected organ's shrinkage and dysfunction. Additionally, some abnormal protein can make these organs cause specific immune response as autoantibody. If kidneys are affected by amyloidosis, Nephrotic Syndrome may occur easily.


If patients' Nephrotic Syndrome is caused by this problem, they can find their kidneys enlarged, and patients are more likely to experience some symptoms.

- Proteinuria

- High blood pressure

- Swelling

- Irregular heartbeat

- Joint pain


In order to prevent kidney failure, patients should take prompt treatment to slow down or even stop the progression of Nephrotic Syndrome and ease patients' complications. From this point, we would like to recommend several suggestions.

- Colchicine: If patients' amyloidosis is due to familiar mediterranean fever, they can use colchicine to reduce the episode of amyloidosis and ease patients' symptoms.

- Cytotoxic agents: The use of these medications can help ease patients' proteinuria and slow down the progression of Nephrotic Syndrome.

- Immunotherapy: This treatment shows a great effective on removing pathogenic factors, providing enough nutrition and oxygen for inherent kidney cells and prompting the recovery of kidney cells. Once kidney filtering structure works normally, patients can find their symptoms are eased a lot.

If you still have any question about Nephrotic Syndrome secondary to amyloidosis, welcome to leave it in the form below. We will reply in 24 hours.

  • Tag: Nephrotic Syndrome Nephrotic Syndrome Basics
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